What is an important factor affecting the absorption of pesticides through the skin?

The size of the skin area exposed is a crucial factor affecting the absorption of pesticides through the skin because the greater the surface area that is in contact with the pesticide, the more potential there is for absorption. When a larger skin area is exposed, there are more pathways for the chemicals to enter the bloodstream, which can lead to higher systemic absorption. Additionally, skin permeability can vary across different areas of the body, which means that even if a small area is exposed, if it's a highly permeable site, absorption can be significant. This principle is important for understanding how to minimize risks when handling pesticides and underscores the need for protective clothing and equipment during pesticide application to limit skin exposure.